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If you take the approach Bitwig took while they don't use rust, they use java for their gui and then use Jni + C code for their dsp.
One could use a tool like tauri to enable using typescript and wasm as well, but java + jni + rust could be a way to go.
But still, AFAIK Bitwig made an in-house GUI toolkit which was based indeed on Java.
The article touches a bit on why a web stack may not be the best solution (see "The web-based toolkits")