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There was some talk on here during Covid about the feasibility of making all structures up to BSL4 standards. Seems kind of nuts, but it would certainly contain a lot of biosafety threats. With AI it now seems borderline urgent.
AirFanta creator Adam Wong has a version using a 3D-printed adapter to 8" circular duct.[0]
In newer builds he places the purifier box indoors and simply reverses the orientation of the fans and filters. This keeps the box protected from weather, and the duct can be run in such a way as to keep out rain or dripping.
The AirFanta is actually rated as EPA E11 (95%) not HEPA H13 (99.97%), so if you're trying to keep out everything in one single pass like a clean room then AirFanta might not be best. It may be a good idea to check the real-world interception performance with a particle counter.
[0] https://x.com/Engineer_Wong/status/2034098395376455946
https://www.reddit.com/r/crboxes/comments/1ef3dly/positive_p...